Blueprint for Precision Oligo Discovery
Prediction Made Better: Our modification-aware platform models duplex binding physics to deliver thermodynamic certainty from sequence to therapy.
De-Risking Oligonucleotide Therapeutics with AccuMatch™
Stop guessing binding affinity. AccuMatch™ delivers thermodynamic certainty for modified duplexes, slashing lead optimization timelines and eliminating costly synthesis failures.
Unrivaled Thermodynamic Precision
The Problem: Standard tools fail to accurately predict how chemical modifications (such as LNA, 2OM, 2′-MOE, DHU, 7dA, m6A or PS linkages) alter duplex stability.
The AccuMatch™ Solution: Our AI-powered predictive analytics platform maps exact binding physics across modified sequences, providing true-to-life thermodynamic profiling before you synthesize a single strand.
Accelerated Lead Optimization
The Problem: Traditional trial-and-error in vitro screening drains capital and delays your development pipeline for drugs, vaccines or therapies by months.
The AccuMatch™ Solution: In silico prediction allows you to screen millions of sequences in just minutes instead of months, focusing your wet-lab resources only on candidates with optimal binding kinetics.
Mitigated Off-Target Toxicity
The Problem: Poorly predicted cross-hybridization creates uncertainty with unexpected safety hurdles late in the preclinical development phase.
The AccuMatch™ Solution: Highly sensitive mismatch discrimination maps off-target binding vulnerabilities early, maximizing therapeutic index and safety at the very early stages of the discovery process.from day one.
Proprietary Algorithms Engineered for Next-Gen Modalities
Our patent-pending thermodynamic engines decode the physics of nucleotide interaction, tailored specifically for the complexities of modern therapeutic architectures.
Technical Modality Breakdown
- Antisense Oligonucleotides (ASOs)
The Physics: High-precision melting temperature (\(T_{m}\)) modeling for DNA:RNA heteroduplexes.
The Impact: Optimizes RNase H-mediated cleavage efficiency by perfectly balancing duplex stability with cellular target accessibility.
- siRNA & RNAi Therapeutics
The Physics: Asymmetry and strand-bias thermodynamic profiling.
The Impact: Predicts guide strand loading into the RISC complex while minimizing passenger strand activity to maximize knockdown potency.
- CRISPR / Cas Guide RNAs
The Physics: Kinetic mapping of gRNA:DNA spacer-target hybridization.
The Impact: Drastically reduces off-target editing risks by accurately flagging single-nucleotide mismatches across the genome.
- Diagnostic Probes & Next-Gen Sequencing (NGS)
The Physics: Multiplex thermodynamic balancing under complex buffer conditions.
The Impact: Ensures uniform capture efficiency and eliminates cross-reactivity in highly multiplexed clinical assays.
How It Works
Our platform enables scientists to model gene probe sequences, and through our statistical algorithms, to predict the melting temperature of the gene probe, to the gene. Melt temperature is the property most critical to gene probe success.
Every 0.1°C Matters
Because ΔG dictates efficacy, precision down to every 0.1°C makes a difference. When probe strength is not matched to the gene, efficiency, specificity, and performance degrade quickly. Our algorithms provide hyper-accurate fractional thermodynamic calculations that prevent off-target binding.
AccuMatch™ Differentiator
DNA Analytics is the first to improve match strength algorithms in over 20 years. Our best-case improvements are up to 7.0° C, compared to the 1998 landmark study of 0.5° C.
AccuMatch Overview
How We Work
Keep It Confidential
We get it, confidentiality is imperative! Before anyone shares anything. we’ll complete a non-disclosure agreement (NDA) to ensure your protection.
The Right Fit
Every need is unique. We’ll work with you to understand your goals and capabilities to identify the right-fit solution, whether it’s the patented AccuMatch Engine Cloud/SaaS solution or the creation of a new Assay Design Pipeline or System.
AccuMatch In Action
See our AccuMatch product demo or setup a custom demo on your own dataset for a live comparison of DNA Analytics’ outputs versus your existing system pipeline.
Delivery And Support
With AccuMatch deployed in the AWS Cloud, our software is delivered quickly. For custom solutions, our design and engineering team will support you through the entire process.
Meet The Team Behind
Our Patent-pending Algorithms
Contact Us
Let's Talk
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